WP 4 – Preclinical back-translation and biological validation

WP4 comprises partners with expertise focus on behavioural and EEG studies (PGI, BI, RUG). This includes the capacity and expertise for chemogenetic activation of OFC neurons innervated by DMN tracts to locally activate or inhibit the specific neural structures that have been identified in the human study, and to test specifically their involvement in the expression of social behaviour. For that purpose, the automated system to monitor individual social behavioural components in group housed animals that was developed and validated in the PRISM project will be used to study the effects of specific neural circuit manipulation on social behaviour. In addition, using EEG, DMN activity will be assessed in relation to social dysfunction in rodents.